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| Product Name | Chloromethylketone EGR (EGRCK) (Biotin) |
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| Description | Determined by HPLC and TLC analyses. EGRCK labeled with biotin is prepared by the method of Williams, et al. (11). Tri-peptide chloromethylketones have been utilized extensively to irreversibly inhibit various serine proteases (1-5). Among the most common chloromethylketones are FPRCK (Phe-Pro-Arg-chloromethylketone), which is a rapid inhibitor of a-thrombin and EGRCK (Glu-Gly-Arg-chloromethylketone), which rapidly inhibits factor Xa (1). Recently, the modification of these tri-peptide chloromethylketones with reporting groups, such as fluorescent probes (6-8), radioactive labels (9) or thioreactive-labels (10), has provided a unique approach to the study of various serine proteases. These probes are useful because they allow a means of reporting molecular changes in an enzyme, and not its zymogen, while also inhibiting the enzymatic activity. The use of biotin as a reporting group has been used extensively with antibodies in ELISA based assays and in Western Blot. The biotin, in conju |
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| Size | 100ug, 1mg |
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| Concentration | n/a |
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| Applications | ELISA IF WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | C5025 |
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| Order / More Info | Chloromethylketone EGR (EGRCK) (Biotin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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