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| Product Name | Endoglin, Mouse, BioAssay™ ELISA Kit (CD105, ENG, END) |
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| Description | Endoglin is a 90kD type I transmembrane glycoprotein of the zona pellucida (ZP) family of proteins. Endoglin and TGF-b RIII/betaglycan are type III receptors for TGF-b superfamily ligands, sharing 71% aa sequence identity within the transmembrane (TM) and cytoplasmic domains. Mouse endoglin cDNA encodes 653aa including a 26aa signal sequence, a 555aa extracellular domain with a two-part ZP domain, a TM domain, and a 47aa cytoplasmic domain. A mouse isoform with a 35aa cytoplasmic domain (S-endoglin) can oppose effects of long (L) endoglin. Endoglin is highly expressed on proliferating vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta, with lower amounts on hematopoietic, mesenchymal and neural crest stem cells, activated monocytes, and lymphoid and myeloid leukemic cells. Endoglin expression can be increased by TGF-b, senescence (S-endoglin in endothelium), stress-induced S100B (in placenta or amnion), or hypoxia. The mouse endoglin ECD shares 69%, 84% |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E2287-04 |
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| Order / More Info | Endoglin, Mouse, BioAssay™ ELISA Kit (CD105, ENG, END) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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