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| Antigenic Specificity | Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | A20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB . It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs . Constitutive expression of A20 is observed in lymphoid tissues , but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha , IL-1 , phorbol esters , and LPS . Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF receptor associated factor) family members , and interaction with the NF-kappaB inhibiting protein ABIN . Studies also show that A20 contains site-specific ubiquitin modifying activity that can contribute to its biological functions . The amino-terminus of A20 contains de-ubiquitinating (DUB) activity for Lys63 branches, such as those found in TRAF6 and RIP, while the carboxyl-terminus contains ubiquitin ligase (E3) activity for Lys48 branches of the same substrates and leads to their degradation . Synonyms: A20, MGC104522, MGC138687, MGC138688, OTUD7C, TNFA1P2, |
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| Immunogen | Recombinant protein of human TNFAIP3 |
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| Other Names | tnfaip3|MGC82339|TNFAIP3|A20|OTUD7C|TNFA1P2|Tnfip3 |
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| Gene, Accession # | Gene ID: 7128,21929,683206 |
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| Catalog # | ABIN1684053 |
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| Price | |
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| Order / More Info | Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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