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| Antigenic Specificity | Myeloid Differentiation Primary Response Gene (88) (MYD88) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. MyD88 was originally isolated as a myeloid differentiation primary response gene that is rapidly induced upon IL-6 stimulated differentiation of M1 myeloleukemic cells into macrophages. It contains an amino-terminal death domain separated from a carboxyl-terminal TIR domain and functions as an adaptor in TLR/IL-1 receptor signaling. The death domain of MyD88 mediates interactions with the IRAK complex triggering a signaling cascade that includes the activation of NF-kappaB.Synonyms: MYD88D |
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| Immunogen | Recombinant protein of human MyD88 |
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| Other Names | XMyD88|myd88d|MGC84928|CG2078|DMMYD88|DmMyD88|DmMyd88|Dmel\\CG2078|EP(2)2535|Kra|LD20892|MYD88|MyD88|Myd88F|dMyD88|dMyd88|kra|myd88|zgc:103541|GB12344|NV10640|irak-2|MYD88D |
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| Gene, Accession # | Gene ID: 4615,17874,301059 |
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| Catalog # | ABIN1514378 |
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| Price | |
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| Order / More Info | Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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