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| Antigenic Specificity | Toll-Like Receptor Adaptor Molecule 1 (TICAM1) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | mouse, rat, human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 50 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses . TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-kappaB, IRF3 and trigger IFN-beta production . Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively . TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-kappaB activation . In addition, TRIF can trigger signaling of that lead to the induction of apoptosis . Synonyms: TRIF, PRVTIRB, TICAM-1 |
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| Immunogen | Recombinant protein of human TICAM1 |
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| Other Names | IIAE6|MyD88-3|PRVTIRB|TICAM-1|TRIF|AW046014|AW547018|trif |
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| Gene, Accession # | Gene ID: 148022,106759,363328 |
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| Catalog # | ABIN1684044 |
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| Price | |
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| Order / More Info | Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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