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| Antigenic Specificity | TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (aa 487-506), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, also known as TAB2, is an enzyme that in humans is encoded by the MAP3K7IP2 gene. The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. TAB2 functionally links TAK1 to TRAF6. What's more, TAB2 can act as a sensor for inflammatory signals by serving as a molecular beacon for recruitment of MEKK1(MAP3K1), which in turn mediated dismissal of the NCOR/HDAC complex and permitted derepression of AR and estrogen receptor target genes. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human TAB2(487-506aa LTNLLNHPDHYVETENIQHL), identical to the related mouse sequence, and different from the related rat sequence by one amino acid. |
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| Other Names | CHTD2|MAP3K7IP2|1110030N06Rik|A530078N03Rik|Map3k7ip2|mKIAA0733|map3k7ip2|zgc:77446 |
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| Gene, Accession # | Gene ID: 23118,68652,308267 |
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| Catalog # | ABIN1889237 |
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| Price | |
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| Order / More Info | TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 2 (TAB2) (aa 487-506), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 16469706 |
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