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| Product Name | STK11, Recombinant, Human, aa1-430, His-SUMO-Tag (Serine/threonine-protein Kinase STK11) |
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| Description | Purity ~90% (SDS-PAGE). Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts by phosphorylating the T-loop of AMPK family proteins, thus promoting their activity: phosphorylates PRKAA1, PRKAA2, BRSK1, BRSK2, MARK1, MARK2, MARK3, MARK4, NUAK1, NUAK2, SIK1, SIK2, SIK3 and SNRK but not MELK. Also phosphorylates non-AMPK family proteins such as STRADA, PTEN and possibly p53/TP53. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA da |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Liver kinase B1, LKB1, hLKB1 Renal carcinoma antigen NY-REN-19 |
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| Gene, Accession, CAS # | SwissProt: Q15831 |
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| Catalog # | 375436 |
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| Order / More Info | STK11, Recombinant, Human, aa1-430, His-SUMO-Tag (Serine/threonine-protein Kinase STK11) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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