| 产品详情 |
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| Product Name | BMP Inhibitor II, DMH1 |
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| Description | Purity ~97% (HPLC). A cell-permeable pyrrazolopyrimidine compound that inhibits against R/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50=25.1, 148, and 234.6nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFbR-I, ZAPK, Syk, PKCth, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100=2.5uM) and VEGF signaling-dependent intersomitic vessel formation (EC50=5uM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR and/or Metformin for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. Formula: C24H20N4O Molecular Weight: 380.4 Solubility: DMSO (16.6mg/ml) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | BMP Inhibitor II, DMH1 (ALK2/3 Inhibitor, DMH1, Bone Morphogenetic Protein Inhibitor, DMH1, 4-(6-(4-Isopropoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217224 |
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| Order / More Info | BMP Inhibitor II, DMH1 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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