| 产品详情 |
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| Product Name | PD 166866 |
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| Description | A potent inhibitor of FGFR1 (IC50 = 52.4 nM; Ki = 45.2 nM); selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 µM); inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively); inhibits phosphorylation of MAPK (IC50 = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively); reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro; inhibits growth of NSCLC cell lines a dose-dependent manner; reduces migration of VL-8 cells at a concentration of 10 µM |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PD166866 FGFR FGF CDK-4 CSRC |
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| Gene, Accession, CAS # | CAS: 192705-79-6 |
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| Catalog # | 22464-5 |
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| Order / More Info | PD 166866 from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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| 产品资料 |
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