| 产品详情 |
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| Product Name | R788 (sodium salt) |
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| Description | Purity >95%. Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that upon phosphorylation binds to immunoreceptor tyrosine-based activation motifs of FcRGamma chains and mediates downstream signaling related to platelet function and inflammation. R788 is a prodrug of R406 , an inhibitor of Syk (Ki = 30 nM). R788 conversion to the biologically active R406 is catalyzed by the action of alkaline phosphatases present on the apical brush-border of the membranes of intestinal enterocytes. It produces anti-inflammatory and immunomodulating effects by inhibiting Syk-mediated IgG FcGamma receptor signaling, which prevents activation of mast cells, macrophages, and B cells, as well as related inflammatory responses. R788 has undergone clinical evaluation for efficacy in the treatment of rheumatoid arthritis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-4-[(phosphonooxy)methyl]-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one, disodium salt, Fostamatinib, NSC 745942, R935788, Tamatinib Fosdium |
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| Gene, Accession, CAS # | CAS: 1025687-58-4 |
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| Catalog # | LS-H9645 |
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| Order / More Info | R788 (sodium salt) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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