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| Product Name | DAXX, Recombinant, Human, aa1-233, GST-Tag (Death Domain-associated Protein 6) |
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| Description | Purity ~90% (SDS-PAGE). Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activatiopn of PAX3 and ETS1 through direct protein-protein interactions. Modulates PAX5 activity; the function seems to involve CREBBP. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Daxx, hDaxx ETS1-associated protein 1, EAP1 Fas death domain-associated protein |
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| Gene, Accession, CAS # | SwissProt: Q9UER7 |
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| Catalog # | 372989 |
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| Order / More Info | DAXX, Recombinant, Human, aa1-233, GST-Tag (Death Domain-associated Protein 6) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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