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| Product Name | POLR3A, Recombinant, Human, aa392-632, His-SUMO-Tag (DNA-directed RNA Polymerase III Subunit RPC1) |
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| Description | Purity ~90% (SDS-PAGE). DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix anates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self R |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | POLR3A, DNA-directed RNA polymerase III subunit RPC1, RNA polymerase III subunit C1, DNA-directed RNA polymerase III largest subunit, DNA-directed RNA polymerase III subunit A, RNA polymerase III 155kD subunit, RPC155, RNA polymerase III |
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| Gene, Accession, CAS # | SwissProt: O14802 |
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| Catalog # | 374790 |
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| Order / More Info | POLR3A, Recombinant, Human, aa392-632, His-SUMO-Tag (DNA-directed RNA Polymerase III Subunit RPC1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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