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| Antigenic Specificity | Homer Homolog 1 (Drosophila) (HOMER1) (Internal Region) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, rat, mouse |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with CENTG1. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.Subcellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note: Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. Also known as: Home1, Homer protein homolog 1, SYN47. |
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| Immunogen | A synthetic peptide from the internal region of human HOMER1 (Home1, Homer protein homolog 1, SYN47) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous with the corresponding sequence in mouse, rat and monkey. |
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| Other Names | HOMER1|homer1|homer|xhomer1|HOMER|HOMER1A|HOMER1B|HOMER1C|SYN47|Ves-1|PSD-Zip45|HOMER1F|Vesl-1|zgc:100854|zgc:92844 |
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| Gene, Accession # | Gene ID: 9456,26556,29546 |
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| Catalog # | ABIN349995 |
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| Price | |
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| Order / More Info | Homer Homolog 1 (Drosophila) (HOMER1) (Internal Region) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 9808459, 12054806, 10464340, 12176012, 17107665, 12379179, 10851183, 9257717, 9808458 |
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