| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Homer Homolog 1 (Drosophila) (HOMER1) (Internal Region) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse, rat, human |
|---|
| Isotype | n/a |
|---|
| Format | serum |
|---|
| Size | 100 µL |
|---|
| Concentration | n/a |
|---|
| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Function: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with CENTG1. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development.Subcellular location: Cytoplasm. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell junction, synapse. Note: Postsynaptic density of neuronal cells. Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. Also known as: Home1, Homer protein homolog 1, SYN47. |
|---|
| Immunogen | A synthetic peptide from the internal region of human HOMER1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in mouse, rat, monkey and xenopus. |
|---|
| Other Names | HOMER1|homer1|homer|xhomer1|HOMER|HOMER1A|HOMER1B|HOMER1C|SYN47|Ves-1|PSD-Zip45|HOMER1F|Vesl-1|zgc:100854|zgc:92844 |
|---|
| Gene, Accession # | Gene ID: 9456,26556,29546 |
|---|
| Catalog # | ABIN350025 |
|---|
| Price | |
|---|
| Order / More Info | Homer Homolog 1 (Drosophila) (HOMER1) (Internal Region) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 9808459, 12054806, 10464340, 12176012, 17107665, 12379179, 10851183, 9257717, 9808458 |
|---|
| 产品资料 |
|
|