| 产品详情 |
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| Antigenic Specificity | beta-Site APP-Cleaving Enzyme 2 (BACE2) (aa 500-550) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | serum |
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| Size | 150 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface Tissue specificity: Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.Synonyms: Aspartic-like protease 56 kDa, Aspartyl protease 1, ASP1, Asp 1, Beta-site amyloid precursor protein cleaving enzyme 2, Beta-site APP cleaving enzyme 2, Down region aspartic protease, DRAP, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, AEPLC, ALP56, ASP21 |
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| Immunogen | A synthetic peptide from aa region 500-550 of human BACE2 conjugated to an immunogenic carrier protein has been used as the antigen. |
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| Other Names | AEPLC|ALP56|ASP1|ASP21|BAE2|CEAP1|DRAP|1110059C24Rik|AI850424|ARP1|CDA13 |
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| Gene, Accession # | Gene ID: 25825,56175,288227 |
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| Catalog # | ABIN1842048 |
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| Price | |
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| Order / More Info | beta-Site APP-Cleaving Enzyme 2 (BACE2) (aa 500-550) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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