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| Antigenic Specificity | beta-Site APP-Cleaving Enzyme 1 (BACE) (C-Term), (aa 485-501) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | cow, rat, mouse, human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 40 µg |
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| Concentration | n/a |
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| Applications | ELISA,Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | beta-secretase, also called BACE (beta-site of APP cleaving enzyme), is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. BACE1, also known as memapsin-2, is the major beta-secretase for generation of the 40 or 42 amino acid-long beta-amyloid peptides that aggregate in the brain of Alzheimer's patients. Extracellular cleavage of APP by BACE1 releases a soluble extracellular fragment and is followed by APP cleavage within its transmembrane domain by gamma-secretase. The second cleavage releases the intracellular domain of APP and beta-amyloid.The immature form of BACE1 contains an N-terminal signal sequence (residues 1-1) followed by a large catalytic domain, a single transmembrane domain (residues 461-77), and a short cytoplasmic domain (residues 478-01). The signal sequence (1-21) is cleaved from the immature form, yielding the proBACE1 protein, which starts at residue 22. The proBACE1 protein is modified by cleavage of 24 N-terminal residues (aa 22-45), producing the mature BACE1 protein.Rabbit Anti-BACE1 (485-501) Polyclonal Antibody is developed in rabbit using a synthetic peptide, CLRQQHDDFADDISLLK, corresponding to amino acids 485-501 at C-terminal of human BACE1.Rabbit Anti-BACE1 (485-501) pAb is highly purified from rabbit antiserum by immunoaffinity chromatography and is supplied as 40 µg aliquots at concentration of 0.5 mg/ml. |
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| Immunogen | A synthetic peptide (KLH conjugated), CLRQQHDDFADDISLLK, corresponding - AA 485-501 at C-terminal of human BACE1 |
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| Other Names | BACE1|MGC145931|bace2|MGC68881|MGC68482|BACE2|C76936|Bace|ASP2|BACE|HSPC104|zgc:77409 |
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| Gene, Accession # | Gene ID: 23621,614333,23821,29392 |
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| Catalog # | ABIN1573951 |
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| Order / More Info | beta-Site APP-Cleaving Enzyme 1 (BACE) (C-Term), (aa 485-501) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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