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| Product Name | D-Mannoheptulose |
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| Description | Purity >98%. D-Glucose is phosphorylated by glucokinase and three tissue-specific hexokinases to produce glucose-6-phosphate in humans. D-Mannoheptulose is a heptose that inhibits glucokinases and hexokinases from diverse organisms through competition with D-glucose (Ki = 0.25 mM). It blocks glucose oxidation and glucose-mediated insulin release from pancreatic islet cells. D-Mannoheptulose prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein. By blocking glucose phosphorylation, D-mannoheptulose causes transient hyperglycemia in dogs when given at 1 g/kg but not at 8 mg/kg, although postprandial energy expenditure is increased at the lower dose. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | D-manno-2-heptulose, NSC 226836 |
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| Gene, Accession, CAS # | CAS: 3615-44-9 |
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| Catalog # | LS-H7503 |
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| Order / More Info | D-Mannoheptulose from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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