| 产品详情 |
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| Product Name | ITF 2357 |
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| Description | Purity >98%. ITF 2357 inhibits class I and class II histone deacetylases (maize HDACs: HD2, HD-1B, and HD-1A with IC50 s = 7.5-16 nM) and reduces the production of several pro-inflammatory cytokines including TNFAlpha, IL-1Alpha, and IL-1Beta (IC50 s = 10-22 nM). ITF 2357 also has activity against cells expressing janus kinase 2 (JAK2)V617F (IC50 s = 1-10 nM), a mutated form of the JAK2 enzyme that is implicated in the pathophysiology of many myeloproliferative diseases, including polycythaemia vera. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[4-[(hydroxyamino)carbonyl]phenyl]-carbamic acid, [6-[(diethylamino)methyl]-2-naphthalenyl]methyl ester, monohydrochloride, monohydrate |
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| Gene, Accession, CAS # | CAS: 732302-99-7 |
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| Catalog # | LS-H8263 |
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| Price | |
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| Order / More Info | ITF 2357 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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