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| Antigenic Specificity | V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) (aa 421-439), (C-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | C-Myc is an oncogene that functions both in the stimulation of cell proliferation and in apoptosis. c-Myc elicits its oncogenic activity by causing immortalization, and to a lesser extent the transformation of cells, in addition to several other mechanisms. The c-MYC proto-oncogene encodes a transcription factor that is critical for cell growth and proliferation. It is one of the genes frequently altered in cancer cells in which it exhibits constitutive activity. Downregulation of c-Myc is critical for 2-Methoxyestradiol(2ME2)-induced oxidative stress and apoptosis in AML cells. And its up-regulation is important for promoting lymphocyte cell division, and demonstrating that GFP-c-Myc expression is a marker of proliferating lymphocytes in vivo. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the C-terminus of human c-Myc(421-439aa RKRREQLKHKLEQLRNSCA), different from the related mouse and rat sequences by one amino acid. |
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| Other Names | LOC100136746|RNCMYC|c-myc|mMyc|AU016757|Myc2|Niard|Nird|bHLHe39|MYC|cmyc|zc-myc|MRTL|MYCC|c-Myc|C-MYC|CMYC|CMyc |
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| Gene, Accession # | Gene ID: 4609 |
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| Catalog # | ABIN1706155 |
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| Order / More Info | V-Myc Myelocytomatosis Viral Oncogene Homolog (Avian) (MYC) (aa 421-439), (C-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 18031614, 16586536, 15334674, 12508351, 11215044, 16944908, 18196973, 18197790, 18206725, 18196519 |
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