| 产品详情 |
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| Product Name | GLK, Recombinant, Human, GST-tag |
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| Description | Purified (~70-90%). GLK is a member of the STE20 family of serine/threonine protein kinases and contains N-terminal catalytic domain and C-terminal regulatory domain. GLK is upstream of the MEKK1 target and is stimulated by UV radiation and TNF and can lead to the activation of the JNK signaling pathway. GLK can directly activate PKC during TCR signaling and people with systemic lupus erythematosus show considerable enhanced GLK expression and activation of PKC and the kinase IKK in T cells. GLK can act as a pro-apoptotic kinase which orchestrates activation of BAX via the concerted post-transcriptional modulation of PUMA, BAD, and BIM. Source: Recombinant protein corresponding to human GLK, fused to GST-Tag at N-terminal expressed in Insect cells. Molecular Weight: ~70kD Specific Activity: 92nmol/min/mg as per activity assay protocol. Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | GLK, Recombinant, Human, GST-Tag (Mitogen-Activated Protein Kinase Kinase Kinase Kinase 3, MAP4K3, MAPKKKK3, MEKKK3, RAB8IPL1) |
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| Gene, Accession, CAS # | Accession: NM_003618 |
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| Catalog # | 500040 |
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| Order / More Info | GLK, Recombinant, Human, GST-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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