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| Product Name | ITGA11, ITGB1, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Integrin a11B1 is a noncovalent, heterdimeric collagen receptor that contains a 150kD a11 subunit complexed to a 130kD B1/CD29 subunit. a11B1 is the only known a11-containing integrin. By contrast, at least twelve a-integrins share the B1 subunit. a11B1 is expressed on fibroblasts from cornea, skin and periodontal ligament (3-9). It is also expressed on mesenchymal stem cells and is considered a marker for non-muscle mesenchymal tissue (3, 8-10). Expression of a11B1 is stimulated by TGF-B1, activin A, and type I interferons, and down-regulated by FGF-2. The a11 extracellular domain (ECD) contains a vWFA domain which includes the ligand binding site. The B1 ECD also contains a vWFA domain, which participates in binding. Each subunit has a transmembrane sequence and a short cytoplasmic tail. The dimer assumes a folded configuration at rest. Divalent cations and intracellular (inside-out) signaling convert it to an active, extended and open conformation. The 1120 |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ITGA11, ITGB1, Recombinant, Human (Integrin alpha 11 beta 1, Integrin alpha-11, MSTP018 / Integrin beta-1, Fibronectin Receptor Subunit beta, VLA-4 Subunit beta, CD29, FNRB, MDF2, MSK12) |
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| Gene, Accession, CAS # | SwissProt: Q9UKX5, Q8K4F0 |
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| Catalog # | I7661-37H |
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| Order / More Info | ITGA11, ITGB1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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