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| Antigenic Specificity | Nucleoporin 98kDa (NUP98) |
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| Clone | 3B8-D7-H10 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | affinity purified |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunoprecipitation (IP) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15. 5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants, however, not all variants have been fully described. Nup98 and Nup96 play a role in the bidirectional transport across the nucleoporin complex (NPC). The repeat domain in Nup98 has a direct role in the transport. Subunit structure: Nup98 interacts directly with Nup96. Nup96 is part of the Nup160 subcomplex in the nuclear pore which is composed of Nup160, Nup133, Nup107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and Nup153 to the nucleus. May interact with RAE1. Interacts with vesicular stomatitis virus protein M. Subcellular location: Nucleus > nuclear pore complex. Nucleus membrane, Peripheral membrane protein, Nucleoplasmic side. Sequence similarities: Belongs to the nucleoporin GLFG family. Contains 1 peptidase S59 domain. |
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| Immunogen | Purified recombinant human NUP98 protein fragments expressed in E.coli. |
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| Other Names | CG10198|CG10201|Dmel\\CG10198|Nup 96|Nup 98|Nup-98|Nup96|Nup98|Nup98-Nup96|Nup98/96|l(3)95BCd|nup145|nup98-96|GB12688|NUP98|4732457F17|AI849286|im:7151238|zgc:113968|zgc:63593|ADIR2|NUP196|NUP96 |
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| Gene, Accession # | Gene ID: 4928 |
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| Catalog # | ABIN1558200 |
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| Price | |
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| Order / More Info | Nucleoporin 98kDa (NUP98) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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