| 产品详情 |
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| Antigenic Specificity | GLE1 |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | purified |
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| Size | 100 ug |
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| Concentration | n/a |
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| Applications | Immunocytochemistry: 5 µg/mL, Immunofluorescence: 5 µg/mL, Immunohistochemistry: 2.5 µg/mL, Western Blot: 1-2 µg/mL |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | GLE1 Polyclonal Antibody. The proper expression of gene products in eukaryotic cells relies on efficient transport of mRNA molecules out of the nucleus. Gle1 is an essential mRNA export factor in both human and yeast cells. It associates with the nuclear pore complex (NPC) through hCG1 and NUP155 in mammalian cells and in conjunction with inositol hexakisphosphate (IP6), stimulates Dbp5, a member of the DEAD-box helicase family, triggering mRNP remodeling and facilitating RNA export from the nucleus. Recent evidence suggests that mutations in Gle1 causing defects in mRNA export can result in human disease. At least three isoforms of Gle1 are known to exist. |
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| Immunogen | n/a |
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| Other Names | GLE1L, LCCS, LCCS1, hGLE1; GLE1-like protein; GLE1-like, RNA export mediator; nucleoporin GLE1 |
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| Gene, Accession # | Entrez: 2733, 362098, 74412; Uniprot: Q4KLN4, Q53GS7, Q8R322 |
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| Catalog # | PA5-20660 |
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| Price | |
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| Order / More Info | GLE1 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | n/a |
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