| 产品详情 |
| Edit |   |
|---|
| Antigenic Specificity | Mouse IL13 |
|---|
| Clone | polyclonal |
|---|
| Host Species | Goat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | n/a |
|---|
| Format | biotin conjugate |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA(Det), WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Goat Anti-Mouse IL13 polyclonal antibody for ELISA(Det), WB. IL-13 is a 17 kDa immunoregulatory cytokine that plays a key role in the pathogenesis of allergic asthma and atopy. It is secreted by Th1 and Th2 CD4+ T cells, NK cells, visceral smooth muscle cells, eosinophils, mast cells, and basophils. IL-13 circulates as a monomer with two internal disulfide bonds that contribute to a bundled four alpha-helix configuration. Mature mouse IL-13 shares 57%, 75%, and 58% amino acid sequence identity with human, rat, and rhesus IL-13, respectively. Despite the low homology, it exhibits cross-species activity between human, mouse, and rat. IL-13 has diverse activities on numerous cell types. On macrophages, IL-13 suppresses the production of proinflammatory cytokines and other cytotoxic substances. On B cells, IL-13 induces immunoglobulin class switching to IgE, upregulates the expression of MHC class II, CD71, CD72, and CD23, and costimulates proliferation. IL-13 upregulates IL-6 while downregulating IL-1 and TNF-alpha production by fibroblasts and endothelial cells. IL-13 binds with low affinity to IL-13 R alpha 1, triggering IL-13 R alpha 1 association with IL-4 R alpha. This high affinity receptor complex also functions as the type 2 IL-4 receptor complex. Additionally, IL-13 binds with high affinity to IL-13 R alpha 2 which is expressed intracellularly, on the cell surface, and as a soluble molecule. IL-13 R alpha 2 regulates the bioavailability of both IL-13 and IL-4 and is overexpressed in glioma and several bronchial pathologies . Compared to wild type IL-13, the atopy-associated R110Q variant of IL-13 elicits increased responsiveness from eosinophils that express low levels of IL-13 R alpha 2. |
|---|
| Immunogen | Recombinant Protein |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | UniProt: P20109 |
|---|
| Catalog # | CABT-L313 |
|---|
| Price | |
|---|
| Order / More Info | Mouse IL13 Antibody from CREATIVE DIAGNOSTICS |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|