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| Product Name | Non CpG-DNA, Human/Mouse |
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| Description | Product Description: The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by CpG motifs occurs via the Toll signal pathway. The Toll-like receptor-9 (TLR9, CD289) appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA, which triggers the induction of cell signaling pathways including the mitogen acti |
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| Size | 200 nmol |
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| Concentration | n/a |
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| Applications | Application Use: For in vitro stimulation, 0.05 to 3 uM can be used. It is recommended that users test the reagent and determine their own optimal concentrations. |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS584641 |
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| Order / More Info | Non CpG-DNA, Human/Mouse from MYBIOSOURCE INC. |
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| Product Specific References | 1. Krieg, A; CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002, 20: 709 2. Weighardt, H; Increased resistance against acute polymicrobial sepsis in mice challenged with immunostimulatory CpG oligodeoxynucleotides is related to an enhanced innate effector cell response. J Immunol 2000, 165: 4537 |
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