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| Product Name | SHP 1, Recombinant, Human |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Src-Homology 2 domain Phosphatase-1 (SHP-1), also known as Protein Tyrosine Phosphatase 1C (PTP1C), PTPN6, and Hematopoetic Cell Phosphatase (HCPH), is an enzyme that selectively dephosphorylates tyrosine residues in proteins. Spontaneous point mutations in the SHP-1 gene in mice produce the ``motheaten'' and motheaten viable'' phenotypes that are severely autoimmune and immunodeficient.1 The enzyme is highly expressed in leukocyte cell types.2 SHP-1 has a regulatory region containing two Src homology 2 (SH2) domains that are critical for its binding to ITIM domains in inhibitory immunoreceptors.3 Deletion of the SH2 domains, as in this product, causes a marked increase in phosphatase activity.4 SHP-1 will dephosphorylate a wide variety of proteins, including the EGF receptor.5 A phosphopeptide containing the EGFR (Y992) sequence can be used to measure the activity of SHP-1 by detecting the release of phosphate. Sourc |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | SHP 1, Recombinant, Human (SHPTP-1, SH2 containing protein tyrosine phosphatase 1, PTP1C, SH-PP1, HCP, SHP, PTPN6) |
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| Gene, Accession, CAS # | SwissProt: P29350 |
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| Catalog # | S1013-25H |
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| Price | |
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| Order / More Info | SHP 1, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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