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| Product Name | NR2C2, Recombinant, Human, aa3-592, His-Tag (Nuclear Receptor Subfamily 2 Group C Member 2) |
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| Description | Purity ~90% (SDS-PAGE). Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Source: Recombinant protein corresponding |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4Testicular receptor 4 |
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| Gene, Accession, CAS # | SwissProt: P49117 |
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| Catalog # | 374467 |
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| Order / More Info | NR2C2, Recombinant, Human, aa3-592, His-Tag (Nuclear Receptor Subfamily 2 Group C Member 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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