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| Product Name | WWTR1, 1-400aa, Human, His tag, E Coli (Denatured) |
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| Description | MW: 46.5kDa (423aa). Purity >85% by SDS-PAGE. WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1 |
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| Size | 0.1 mg, 0.5 mg |
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| Concentration | 0.5 mg/ml (determined by Bradford assay) |
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| Applications | SDS-PAGE |
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| Other Names | [WW domain containing transcription regulator 1; TAZ] |
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| Gene, Accession, CAS # | WWTR1, Gene ID: 25937, Accession: NP_001161752 |
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| Catalog # | MBS205134 |
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| Order / More Info | WWTR1, 1-400aa, Human, His tag, E Coli (Denatured) from MYBIOSOURCE INC. |
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| Product Specific References | Huang,W., et al. (2012) J. Biol. Chem. 287 (31), 26245-26253; Pan,J., et al. (2012) Oncol. Rep. 28 (1), 179-185; |
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