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| Product Name | WWTR1, Recombinant, Human, aa1-400, His-Tag |
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| Description | Purity ~85% (SDS-PAGE). WWTR1 is a transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Source: Recombinant corresponding to aa1-400 from human WWTR1 protein, fused to His-tag at N-terminus, expressed in E.coli. Molecular Weight: ~46.5kD (423aa) Applications: Suitable for use in SDS-PAGE. |
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| Size | 100ug, 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | WWTR1, Recombinant, Human, aa1-400, His-Tag (WW Domain Containing Transcription Regulator 1, Transcriptional Coactivator with PDZ-binding Motif, TAZ) |
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| Gene, Accession, CAS # | Accession: NP_001161752 |
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| Catalog # | 218678 |
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| Price | |
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| Order / More Info | WWTR1, Recombinant, Human, aa1-400, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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