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| Product Name | KCTD11, GST-Tag, Recombinant (C17orf36, REN, KCASH1, REN/KCTD11, BTB/POZ Domain-Containing Protein KCTD11) |
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| Description | Lysate. Play a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcrition factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade. Source: Partial length protein corresponding to of KCTD11, fused to GST-Tag at N-terminal, expressed in E. coli. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Optimal dilutions to be determined |
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| Size | 200ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | KCTD11, Gene ID: 147040, Accession: NP_001002914, SwissProt: Q693B1 |
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| Catalog # | 500800 |
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| Order / More Info | KCTD11, GST-Tag, Recombinant (C17orf36, REN, KCASH1, REN/KCTD11, BTB/POZ Domain-Containing Protein KCTD11) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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