| 产品详情 |
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| Product Name | OSI-027 |
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| Description | Purity >98%. The mammalian target of rapamycin (mTOR) is a serine-threonine kinase that is central to two protein complexes, mTORC1 and mTORC2. These complexes are differentially regulated (e.g., only mTORC1 is sensitive to rapamycin ) and regulate different pathways. OSI-027 is an inhibitor of the catalytic site of mTOR and, as a result, inhibits both mTORC1 and mTORC2 (IC50 s = 22 and 65 nM, respectively). It is selective for mTOR over phosphatidylinositol 3-kinase isoforms and DNA protein kinase. OSI-027 prohibits proliferation, induces autophagy, and potentiates apoptosis in BCR-ABL transformed cells and other cancer cells at 10 µM. OSI-027 is effective in vivo, blocking the phosphorylation of targets of mTORC1 and mTORC2 and suppressing tumor growth in several different human xenograft models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | trans -4-[4-amino-5-(7-methoxy-1H-indol-2-yl)imidazo[5,1-f][1,2,4]triazin-7-yl]-cyclohexanecarboxylic acid |
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| Gene, Accession, CAS # | CAS: 936890-98-1 |
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| Catalog # | LS-H9210 |
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| Price | |
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| Order / More Info | OSI-027 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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