| 产品详情 |
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| Product Name | PP1 |
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| Description | MW: 281.4. Purity >99% (TLC); NMR (Conforms). Src family kinase inhibitorPharmacology: Inhibits NGF receptor tyrosine kinase (TrkA, pp140trk). Inhibits NGF-induced neurite outgrowth in PC12 cells1. Displays antitumor activity in a mouse model2. Blocks the ETK-PAK1 interaction, suppressing RAS-induced PAK1 activation and malignant transformation3. Cell permeable.Scientific Background: Potent and selective inhibitor of Src family tyrosine kinases. IC50=5 nM (p65lck), IC50=6 Nm ( |
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| Size | 5 mg, 25 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [AG-879; alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide; 4-Amino-1-tert-butyl-3-(4-methylphenyl) pyrazolo [3,4-d] pyrimidine] |
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| Gene, Accession, CAS # | CAS: 172889-26-8 |
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| Catalog # | MBS515049 |
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| Order / More Info | PP1 from MYBIOSOURCE INC. |
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| Product Specific References | 1. M Ohmichi et al. Biochemistry 1993 32:4650 2. M Rende et al. Anticancer Drugs 2006 17:929 3. H He et al. Cancer Biol. Ther. 2004 3:96 |
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