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| Product Name | SNIP1, Recombinant, Human, aa258-396, His-Tag (Smad nuclear interacting protein 1) |
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| Description | Purity ~90% (SDS-PAGE). SNIP1 is smad nuclear interacting protein contains a forkhead-associated (FHA) domain and acts as a nuclear inhibitor of CBP/p300. This protein is an inhibitor of the TGF-beta signal transduction pathway and to be important in suppressing transcriptional activation dependent on the co-activators CBP and p300. Inhibition of NF-kappa B activity is a function of the N-terminal domain of SNIP1 and involves competition of SNIP1 and the NF-kappa B subunit, RelA/p65, for binding to p300, similar to the mechanism of inhibition of Smad signaling by SNIP1. Purified by using conventional chromatography techniques. Source: Recombinant human corresponding to aa258-396 of SNIP1, fused to His-tag at N-terminus, expressed in E.coli. AA Sequence: MGSSHHHHHH SSGLVPRGSH MRWRLYPFKN DEVLPVMYIH RQSAYLLGRH RRIADIPIDH PSCSKQHAVF QYRLVEYTRA DGTVGRRVKP YIIDLGSGNG TFLNNKRIEP QRYYELKEKD VLKFGFSSRE YVLLHESSDT SEIDRKDDED EEEEEEVSDS Molecular Weight: ~18.8kD (160aa) confirmed by MALDI-TOF |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_078976 |
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| Catalog # | S1014-96D |
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| Order / More Info | SNIP1, Recombinant, Human, aa258-396, His-Tag (Smad nuclear interacting protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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