| 产品详情 |
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| Product Name | KP372-1 |
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| Description | Purity >95%. KP372-1 is a specific Akt inhibitor that demonstrates at least 10-fold selectivity against a panel of additional kinase targets, including CDK1, ERK1, GSK3Beta, LCK, MEK1, PKA, PKC, and S6K. By blocking Akt signaling, KP372-1 has been shown to inhibit proliferation and to induce apoptosis of thyroid cancer cells with an IC50 value of 30-60 nM in vitro . In acute myelogenous leukemia cells, KP372-1 is reported to inhibit the kinase activity of Akt, PDK1, and FLT3, decreasing the colony-forming ability of these cells with an IC50 value less than 200 nM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 6H-indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one, compd. with 10H-indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one (1:1) |
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| Gene, Accession, CAS # | CAS: 1374996-60-7 |
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| Catalog # | LS-H8361 |
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| Price | |
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| Order / More Info | KP372-1 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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