| 产品详情 |
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| Product Name | 3-AP |
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| Description | Purity >95%. Ribonucleotide reductase, the rate-limiting enzyme for de novo DNA synthesis, is an excellent target for chemotherapy. Its increased activity in cancer cells is associated with malignant transformation and proliferation. 3-AP is a ribonucleotide reductase inhibitor and iron chelator with antitumor activity. At 5 µM it can enhance DU145, U251, and PSN1 tumor cell radiosensitivity in vitro, inhibiting DNA synthesis and repair. It destroys the tyrosine free radical in the R2/p53R2 subunits of ribonucleotide reductase by forming a redox active complex with iron, thus producing reactive oxygen species. Furthermore, 3-AP has been shown to activate an endoplasmic reticulum stress pathway, leading to the unfolded protein response and apoptosis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(3-amino-2-pyridinyl)methylene]-hydrazinecarbothioamide, 3-Aminopyridine-2-Carboxyaldehyde Thiosemicarbazone, NSC 663249, Triapine™ |
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| Gene, Accession, CAS # | CAS: 143621-35-6 |
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| Catalog # | LS-H6046 |
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| Order / More Info | 3-AP from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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