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| Product Name | C-Cbl, active, Recombinant, Human, GST-Tag |
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| Description | Purity ~75% (SDS-PAGE, Coomassie blue staining). Intracellular signals mediated by receptor tyrosine kinases play a pivotal role in morphogenesis, cell fate determination and pathogenesis. c-Cbl is a ubiquitin ligase (E3) that facilitates the regulation of these pathways, attenuating signalling through ubiquitination and subsequent protein degradation. c-Cbl contains several functional domains, including a tyrosine kinase-binding domain that associates with a number of protein tyrosine kinases in a phosphorylation-dependent manner, a catalytic RING-finger domain that interacts with E2s and is essential for E3 activity and a C-terminal proline rich domain which mediates interactions with SH3 containing proteins. Mutations in the gene for c-Cbl have been implicated in a number of human cancers, particularly acute myeloid leukaemia. Source: Recombinant protein corresponding to full length human c-Cbl, fused to GST-tag at N-terminal, expressed by baculovirus in Sf21 insect cells Molecular |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | C-Cbl, active, Recombinant, Human, GST-Tag (E3 ubiquitin-protein ligase CBL, Casitas B-lineage lymphoma proto-oncogene, RING finger protein 55, Signal transduction protein CBL, CBL2, RNF55) |
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| Gene, Accession, CAS # | Accession: NM_005188 |
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| Catalog # | 29430 |
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| Order / More Info | C-Cbl, active, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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