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| Product Name | RhoA/Rac1/CDC42 Activation Assay Combo Kit |
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| Description | Background: Small GTP-binding proteins (or GTPases) are a family of proteins that serve as molecular regulators in signaling transduction pathways. RhoA, Rac1 and Cdc42, 21 kDa proteins, belong to the family of Rho GTPases regulates a variety of biological response pathways that include cell motility, cell division, gene transcription, and cell transformation. Like other small GTPases, RhoA, Rac1 and Cdc42 regulate molecular events by cycling between an inactive GDP-bound form and an active GTP- |
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| Size | 30 assays |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS168321 |
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| Order / More Info | RhoA/Rac1/CDC42 Activation Assay Combo Kit from MYBIOSOURCE INC. |
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| Product Specific References | 1. Ren X.D. and Schwartz M. A. (2000) Methods Enzymol. 325:264-72.11 2. Raftopoulou M., and Hall A. (2004) Dev Biol. 265:23-32.3. Bar-Sagi D., and Hall A. (2000) Cell 103:227-38.4. Benard, V., Bohl, B. P., and Bokoch, G. M. (1999) J. Biol. Chem. 274:13198-13204.1. Wang, J. et al. (2013). DEK Depletion Negatively Regulates Rho/ROCK/MLC Pathway in Non-Small Cell Lung Cancer.Journal of Histochemistry & Cytochemistry. 10.1369/0022155413488120.2. Quint, P. et al. (2013). Sphingosine 1-Phosphate (S1P) Receptors 1 and 2 Coordinately Induce Mesenchymal Cell Migration through S1P Activation of Complementary Kinase Pathways. J. Biol. Chem. 288:5398-5406.3. Yu, X. et al. (2012). RhoGDI SUMOylation at Lys-138 Increases Its Binding Activity to Rho GTPase and Its Inhibiting Cancer Cell Motility. J.Biol. Chem. 287:13752-13760.4. Baranwai, S. et al. (2011). Molecular Characterization of the Tumor-Suppressive Function of Nischarin in Breast Cancer. J. Natl Cancer Inst. 10.1093/jnci/djr350.5. Tian, D. et al. (2010). Antagonistic Regulation of Actin Dynamics and Cell Motility by TRPC5 and TRPC6 Channels. Sci. Signal. 3:ra77.6. Xu, Y. et al. (2010). Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J. Cell Biol. 188:115130.7. Ma, T. el al. (2010). Viral G protein-coupled receptor up-regulates Angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi's sarcoma. PNAS 104:14363-14368.8. Mohseni, M. et al. (2008). The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activity. Mol. Cell. Biol. 28:4712-4718.9. Liu, Y. et al. (2008). Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts. Glycobiology 18:593-601.10. Qu, Y. et al. (2008). Enhanced migration and CXCR4 over-expression in fibroblasts with telomerase reconstitution. Mol. and Cell. Biochem. 313:45-52. |
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