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| Product Name | GPI-16552 |
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| Description | Purity >98% by NMR, TLC. GPI-16552 is a novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 uM. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma. GPI-16552 synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-bis-(3-Phenyl-propyl)-9-oxo-fluorene-2,7-diamide |
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| Gene, Accession, CAS # | CAS: 443794-40-9 |
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| Catalog # | LS-H14689 |
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| Order / More Info | GPI-16552 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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