| 产品详情 |
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| Antigenic Specificity | CD244 |
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| Clone | eBioPP35 (PP35) |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 25 µg |
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| Concentration | n/a |
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| Applications | Flow Cytometry: Assay-Dependent, Immunoprecipitation: Assay-Dependent, Western Blot: Assay-Dependent |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD244 Monoclonal Antibody (eBioPP35 (PP35)), eBioscience™. CD244 (2B4, SLAMF4) is a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via CD244 is thought to modulate NK-cell cytolytic activity. CD244 interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in the pathology of this autoimmune disease. Diseases associated with CD244 dysfunction include rheumatoid arthritis and lymphoprolif |
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| Immunogen | n/a |
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| Other Names | 2B4, NAIL, NKR2B4, Nmrk, SLAMF4 |
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| Gene, Accession # | Entrez: 51744; Uniprot: Q9BZW8 |
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| Catalog # | 14-2449-80 |
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| Order / More Info | CD244 Antibody from INVITROGEN ANTIBODIES |
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| Product Specific References | PubMed: 22661557 |
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| 产品资料 |
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