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| Product Name | CD117, Recombinant, Human |
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| Description | Purity ≥ 90% by SDS-PAGE. C-Kit is the receptor tyrosine kinase for stem cell factor (SCF) and is a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors (1,2). It plays critical controlling roles in a number of cell types such as hematopoietic stem cells, mast cells, melanocytes and germ cells (3). Upon binding with its ligand, c-Kit receptors are induced undergoing dimerization/ oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCgamma, p85 subunit of PI3 kinase, SHP2 and CrkL (4), which links c-Kit directly to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders (5), while mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors (6). Tyrosine 719 is located in the kinase insert |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD117, Recombinant, Human (c-kit, Stem Cell Factor, SCF Receptor, Steel Factor Receptor, Mast Cell Growth Factor, MGF) |
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| Gene, Accession, CAS # | Accession: BC071593 |
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| Catalog # | C2448-23B |
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| Price | |
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| Order / More Info | CD117, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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