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| Product Name | CD30, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). CD30, also known as Ki-1 antigen and , is a 120kD type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Mature human CD30 consists of a 361aa extracellular domain with six cysteine-rich repeats, a 28aa transmembrane segment, and a 188aa cytoplasmic domain. In contrast, mouse and rat CD30 lack 90aa of the ECD and contain only three cysteine-rich repeats. Within common regions of the ECD, human CD30 shares 53% and 49% aa sequence identity with mouse and rat CD30, respectively. Alternate splicing of human CD30 generates an isoform that includes only the C-terminal 132aa of the cytoplasmic domain. CD30 is normally expressed on antigen-stimulated Th cells and B cells. However, it is up-regulated in Hodgkin's disease (on Reed-Sternberg cells), other lymphomas, chronic inflammation, and autoimmunity. CD30 binds to CD30 Ligand/ TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells. CD30 sign |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD30, Recombinant, Human (TNFRSF8, Tumor Necrosis Factor Receptor Superfamily Member 8, CD30L Receptor, Ki-1 Antigen, Lymphocyte Activation Antigen CD30, D1S166E) |
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| Gene, Accession, CAS # | SwissProt: P28908 |
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| Catalog # | C2382-15 |
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| Order / More Info | CD30, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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