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| Product Name | PRF1, Recombinant, Human, aa22-555, His-SUMO-Tag (Perforin-1) |
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| Description | Purity ~90% (SDS-PAGE). Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Plays an important role in killing other cells that are recognized as non-self by the immune system, e.g. in transplant rejection or some forms of autoimmune disease. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes. Source: Recombinant protein corresponding to aa22-555 from human PRF1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~75.2kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Cytolysin, Lymphocyte pore-forming protein, PFP |
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| Gene, Accession, CAS # | SwissProt: P14222 |
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| Catalog # | 374840 |
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| Order / More Info | PRF1, Recombinant, Human, aa22-555, His-SUMO-Tag (Perforin-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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