| 产品详情 |
| Edit |   |
|---|
| Product Name | Manumycin A |
|---|
| Description | Purity >98%. Manumycin A is an antibiotic that acts as a potent and selective farnesyltransferase (FTase) inhibitor with anti-tumor activity. It inhibits rat brain FTase with a Ki value of 1.2 µM, thereby preventing Ras activation which requires farnesylation at the C-terminus for membrane attachment. It exhibits significant antitumor activity against Ki -ras-activated solid tumors in mice at a dose of 6.3 mg/kg. Manymycin A inhibits I?B kinase (IKK), independent of FTase inhibition, in an number of cells types with effective concentrations of 2-10 µM. In ApoE-deficient mice, Manumycin A treatment for 22 weeks at 5 mg/kg reduced aortic fatty streak lesion size to 43% of vehicle-treated animals, indicating FTase inhibition as a potential target for prevention or treatment of atherosclerosis. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | N-[(1S,5S,6R)-5-hydroxy-5-[(1E,3E,5E)-7-[(2-hydroxy-5-oxo-1-cyclopenten-1-yl)amino]-7-oxo-1,3,5--heptatrien-1-yl]-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl]-2E,4E,6R-trimethyl,2,4-decadienamide, NSC 622141, UCF 1C |
|---|
| Gene, Accession, CAS # | CAS: 52665-74-4 |
|---|
| Catalog # | LS-H8598 |
|---|
| Price | |
|---|
| Order / More Info | Manumycin A from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|