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| Product Name | Human IGF-1R Recombinant (CD221) |
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| Description | MW: 15,940 Da. Purity >95%, as determined by SDS-PAGE and HPLC. Insulin-like growth factor 1 receptor (IGF-1R/CD221) is a membrane-associated tyrosine kinase receptor that plays an important role in cell growth, transformation, and protection of cells from a variety of apoptotic stimuli. IGF-1R (CD221) is a tetrameric receptor consisting of two -subunits and two transmembrane β- subunits that are linked by disulfide bonds.The - subunits are extracellular and bind IGF. Each transmembrane |
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| Size | 0.02 mg, 0.1 mg, 0.5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Human CD221 Recombinant (IGF1 Receptor) ; cd-221; CD221; IGFIR; JTK13; MGC142170; MGC142172; MGC18216; IGF1 Receptor; IGF-1R; IGF-IR] |
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| Gene, Accession, CAS # | CD221, Accession: P68069.2 |
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| Catalog # | MBS553175 |
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| Order / More Info | Human IGF-1R Recombinant (CD221) from MYBIOSOURCE INC. |
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| Product Specific References | • autocrine igf-1/IGF-1R signalling is responsible for constitutive pi3k/akt activation in acute myeloid leukemia: therapeutic value of neutralizing anti-IGF-1R antibody .Haematologica, Dec 2009; 10.3324/haematol.2009.010785. • mir-29 micrornas regulate IGF-1R expression and contribute mantle cell lymphoma growth and survival. .Blood (ASH Annual Meeting Abstracts), Nov 2009; 114: 1957. • IGF-1R contributes to stress-induced hepatocellular damage in experimental cholestasis .Am. J. |
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