| 产品详情 |
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| Product Name | Aggrecan, Recombinant, Interglobular Domain |
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| Description | Recombinant aggrecan interglobular domain appears as a major band at about 21kD in SDS-PAGE, representing ≥ 90% of total protein in the preparation. Aggrecan is a large aggregating proteoglycan of articular cartilage. It is also found in aorta, discs and tendons (1,2). The aggrecan core protein consists of 2317aa (2). Up to 130 glucosaminoglycan chains are attached to the core protein. The total molecular mass can reach 2.2-3 x 10e3kD (4). Within the aggrecan molecule, 3 global domains G1, G2 and G3 can be distinguished. Domains G1 and G2 are connected by a rod-shaped polypeptide called interglobular domain (IGD). The sequence between domains G2 and G3 contains attachment regions for keratan sulfate and chondroitin sulfate chains. Aggrecan interacts via the G1domain with hyaluronan and link protein to form large aggregates. Such aggregates can contain up to 50-100 aggrecan monomers noncovalently bound to a single hyaluronan chain through 2 link proteins (1,2,4). The aggregates form a h |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | Aggrecan, Recombinant, Interglobular Domain (Aggrecan IgD1, Proteoglycan, PG, AGC 1, Aggrecan 1, Antigen identified by monoclonal A0122, Cartilage specific proteoglycan core protein, Chondroitin sulfate proteoglycan core protein 1, CSPCP, CSPG1, CSPGCP, Large aggregating proteoglycan, MSK16, SEDK) |
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| Gene, Accession, CAS # | SwissProt: P16112 |
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| Catalog # | A1059-53B |
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| Order / More Info | Aggrecan, Recombinant, Interglobular Domain from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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