| 产品详情 |
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| Product Name | Darapladib |
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| Description | Purity >98%. Lipoprotein-associated phospholipase A2 (Lp-PLA2 ), also known as platelet activating factor acetylhydrolase (PAF-AH) or phospholipase A2 group 7 (PLA2G7), hydrolyzes glycerophospholipids to produce lyso-PAF/lyso-phosphatidylcholine and short and/or oxidized fatty acids, many of which have pro-inflammatory or pro-oxidative activities. Darapladib is a reversible inhibitor of Lp-PLA2 (IC50 = 0.25 nM). It produces sustained inhibition of plasma Lp-PLA2 activity in humans receiving intensive atorvastatin therapy. Lp-PLA2 inhibition with darapladib also reduces the development of coronary atherosclerotic plaques. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(diethylamino)ethyl]-2-[[(4-fluorophenyl)methyl]thio]-4,5,6,7-tetrahydro-4-oxo-N-[[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]methyl]-1H-cyclopentapyrimidine-1-acetamide, SB-480848 |
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| Gene, Accession, CAS # | CAS: 356057-34-6 |
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| Catalog # | LS-H7363 |
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| Price | |
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| Order / More Info | Darapladib from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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