| 产品详情 |
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| Product Name | Darglitazone |
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| Description | Purity >95%. Thiazolidinediones (TZDs) are a group of structurally related peroxisome proliferator-activated receptor Gamma (PPARGamma) agonists with antidiabetic actions in vivo . Darglitazone is a TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations by increasing the expression of the p85 subunit of PI3K. It increases insulin effectiveness in obese non-insulin-dependent diabetes mellitus subjects. Darglitazone promotes adipocyte differentiation by up-regulating the expression of uncoupling protein-2. Through PPARGamma, darglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia and reduces infarct size in diabetic ob/ob mice. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[[4-[3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-2,4-thiazolidinedione, CP 86,325 |
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| Gene, Accession, CAS # | CAS: 141200-24-0 |
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| Catalog # | LS-H7366 |
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| Order / More Info | Darglitazone from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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