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| Product Name | Reversine |
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| Description | Purity >98%. Reversine is a 2,6-disubstituted purine derivative that was originally found to induce dedifferentiation of C2C12 culture myoblast cells into stem cell progenitors when used at a concentration of 5 µM for four days. Depending on cell type, reversine promotes either differentiation or dedifferentiation. For example, in NT2 neuronal and HL-60 human promyelocytic leukemia cells, it induces differentiation. It inhibits the Aurora A, B, and C kinases with IC50 values of 98-876 nM and acts as an antagonist at the adenosine A3 receptor with a Ki value of 0.66 µM. Reversine is also used for studies of chromosome segregation. It inhibits the mitotic spindle checkpoint enzyme MPS1 with IC50 values of 6 and 2.8 nM for its kinase domain and full-length version, respectively). Reversine induces autophagy in WRO human follicular thyroid cancer cells and decreases Akt/mTOR signaling. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N6 -cyclohexyl-N2 -[4-(4-morpholinyl)phenyl]-9H-purine-2,6-diamine |
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| Gene, Accession, CAS # | CAS: 656820-32-5 |
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| Catalog # | LS-H9694 |
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| Order / More Info | Reversine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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