| 产品详情 |
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| Product Name | TSLP, Recombinant, Human (Thymic Stromal Lymphopoietin) |
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| Description | Purity ~97% (SDS-PAGE, HPLC). TSLP protein is a hemopoietic cytokine which signals throughout a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the Interleukin-7 receptor alpha chain. TSLP impacts myeloid cells thus induces the discharge of T cell-attracting chemokines from monocytes and increases the growth of CD11c(+) dendritic cells. TSLP is mainly expressed in the heart, liver and prostate. TSLP is related in its biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the Interleukin-7 receptor alpha chain and the TSLPR. Similar to IL-7, TSLP enhances phosphorylation of STAT3 and STAT5, though uses kinases excluding JAKs for its activation. TSLP induces the release of T cell-attracting chemokines such as TARC and MDC from monocytes & triggers CD11c(+) dendritic cells. TSLP activated dendritic cells primes naive T cells to manufacture pro-allergic cytokines such as Iinterleukin-4, Interleukin-5, Interle |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Thymic Stromal Lymphopoietin |
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| Gene, Accession, CAS # | TSLP, Gene ID: 85480, SwissProt: Q969D9 |
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| Catalog # | 220357 |
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| Order / More Info | TSLP, Recombinant, Human (Thymic Stromal Lymphopoietin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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