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| Product Name | TSLP, Recombinant, Human (Thymic Stromal Lymphopoietin) |
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| Description | Purity ~98% (SDS-PAGE and HPLC). TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R alpha chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naive T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNF) while down-regulating IL-10 and IFN-? suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15kD protein consisting of 132aa. Source: Recombinant protein corresponding to human TSLP, expressed in E.coli. Endotoxin |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149650 |
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| Order / More Info | TSLP, Recombinant, Human (Thymic Stromal Lymphopoietin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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